1. [I]nfo
  2. [M]oduli
  3. [B]acheca
  4. [P]rogramma
  5. [O]rari
  6. [E]sami
  7. E[v]enti
  8. [F]iles

Generali:

  • Dipartimento: Scienze Matematiche, Fisiche E Naturali
  • Codice di verbalizzazione: 8068048
  • Metodi di insegnamento: Frontale E Altro
  • Metodi di valutazione: Scritto E Orale
  • Prerequisiti: To fully understand lesson contents and achieve the expected learning outcomes, knowledge of basic concepts on general biochemistry, cell biology and histology, physiology, immunology and pathology acquired during the Bachelor��s degree will be essential.
  • Obiettivi: LEARNING OUTCOMES: This course offer an in-depth analysis of the biochemical and cellular mechanisms underlying major neurodegenerative diseases and cancer�"immune interactions, and of the application of advanced experimental models. The Biochemistry of Neurodegeneration: from Basics to Models module will focus on the unique metabolic features of the nervous system and how these are disrupted in disease. It covers the key pathological mechanisms associated with neurodegeneration, including protein and RNA aggregation, mitochondrial dysfunction, and neuroinflammation. Additionally, it presents experimental models commonly used in this field�"ranging from iPSC-derived glial cells and neurons to brain organoids and animal models�"and introduces emerging therapeutic approaches. The Cellular Oncology: from basics to models module emphasizes the application of advanced cellular models�"including 2D cultures, 3D organoids, and induced pluripotent stem cells (iPSCs)�"to faithfully recapitulate tumor heterogeneity and microenvironmental factors. Furthermore, the course covers in vivo models such as genetically engineered mouse models (GEMMs) and patient-derived xenografts (PDXs), which are pivotal for studying tumor biology and evaluating preclinical therapeutic strategies. Through these modules, will gain insight into the translational continuum from basic research in neurodegenerative diseases and cancer to clinical application. Upon completion of the course, students will be able to demonstrate a solid understanding of the molecular and cellular basis of neurodegeneration and cancer, effectively apply advanced in vitro and in vivo models to the study of neurodegenerative and oncological processes, and critically assess the translational relevance of experimental results in both fields. KNOWLEDGE AND UNDERSTANDING: Students will acquire a thorough knowledge of the key biochemical and cellular processes involved in neurodegenerative diseases and cancer initiation and progression. They will become familiar with current experimental models used in both research areas, including 2D cultures, 3D organoids, iPSCs, and animal models. APPLYING KNOWLEDGE AND UNDERSTANDING: The course aims to provide students with the ability to describe and explain biological mechanisms of neurodegeneration and tumorigenesis using biochemical and cellular approaches. Students will learn to interpret and discuss scientific literature and understand how to use experimental models to evaluate preclinical therapeutic strategies, effectively bridging basic research and clinical application. MAKING JUDGEMENTS: Students will develop critical thinking skills to assess the strengths and limitations of various experimental models. They will be able to evaluate the translational potential of data generated from these models and make informed decisions regarding model selection and experimental design for specific research questions. COMMUNICATION SKILLS: Students will develop proficiency in the use of scientific terminology and learn to structure and communicate research findings logically and effectively in the contexts of neurodegenerative disease and cancer biology. LEARNING SKILLS: Students will enhance their ability to use scientific literature and reference texts to interpret and synthesize complex information. They will gain competence in describing and applying experimental and therapeutic models to address key questions in neurodegeneration and oncology, integrating the multifaceted nature of disease mechanisms at the cellular level.
  • Ricevimento: Martedi' 14-16

Didattica:

  • A.A.: 2025/2026
  • Canale: UNICO
  • Crediti: 6
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